WMBGS research talk 2016

CRN workforce and structure

  • 15 Local Clinical Research Networks
  • National Coordinating Centre
  • Network funded staff in NHS hospital trusts, Universities and other health and social care settings
  • 30 clinical specialties managed via six specialty cluster leads with oversight from the CRN Executive Team

How the CRN works

The CRN supports studies by:

  • Funding research support posts in the NHS and providing training, so that researchers have access to experienced front-line staff, who can carry out the additional practical activities required
  • Providing funding to meet the costs of using facilities, such as scanners and X-rays that are needed
  • Helping identify and recruit patients, so that researchers can be confident of completing the study on time, and on target

CRN: high level objectives

  1. Increase the number of participants recruited into NIHR CRN Portfolio studies
  2. Increase the proportion of studies in the NIHR CRN Portfolio delivering to recruitment time and target
  3. Increase the number of commercial contract studies delivered through the NIHR CRN
  4. Reduce the time taken for eligible studies to achieve set up in the NHS
  5. Reduce the time taken to recruit first participant into NIHR CRN Portfolio studies
  6. Increase NHS participation in NIHR CRN Portfolio studies
  7. Increase the number of participants recruited into Dementias and neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio

Breakthrough research
Argus II study (Bionic eye) – Second Sight sponsored study

  • In July 2015, a partially sighted 80 year old man had his central vision restored after he received a bionic eye following being recruited to a Network study
  • World’s first patient with advanced age-related macular degeneration (AMD) to receive the implant

LUMINOUS – a Novartis sponsored study (2011-2015)

  • Long-term safety and effectiveness of Ranibzumab for all licenced indications
    Recruitment target of 30,000 globally
  • UK was top recruiter globally – contributing over 11,000 patients across indications
  • 49 UK sites active with subjects
  • Top two recruiting sites for neovascular AMD globally were from the UK

Delivering research

The NIHR CRN supports the delivery of non-commercial and commercial research

Non-commercial research
The NIHR CRN provides guidance on the practical aspects of delivering study in the NHS environment, including;

  • Support for study planning
  • Support for study set-up and delivery

Commercial research
The NIHR CRN oversees the set-up and delivery of various types of commercial research across the UK, such as;

  • Feasibility
  • Set-up
  • Performance management